Presence of Fetal RNA in Maternal Plasma

Presence of fetal RNA in maternal plasma.

Presence of fetal DNA in maternal plasma and serum.

BACKGROUND The potential use of plasma and serum for molecular diagnosis has generated interest. Tumour DNA has been found in 'the plasma and serum of cancer patients, and molecular analysis has been done on this material. We investigated the equivalent condition in pregnancy-that is, whether fetal DNA is present in maternal plasma and serum. METHODS We used a rapid-boiling method to extract ...

Size distributions of maternal and fetal DNA in maternal plasma.

BACKGROUND The discovery of fetal DNA in maternal plasma has opened up an approach for noninvasive prenatal diagnosis. Despite the rapid expansion in clinical applications, the molecular characteristics of plasma DNA in pregnant women remain unclear. METHODS We investigated the size distribution of plasma DNA in 34 nonpregnant women and 31 pregnant women, using a panel of quantitative PCR ass...

Fetal nucleic acids in maternal plasma.

The discovery of cell-free fetal nucleic acids in maternal plasma has opened up new possibilities for noninvasive prenatal diagnosis. Over the last few years, a number of approaches have been demonstrated to allow such circulating fetal nucleic acids to be used for the prenatal detection of chromosomal aneuploidies. One such approach involves the enrichment of fetal DNA, such as by size fractio...

Fetal RHD Genotyping Using Maternal Plasma

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